An advanced formulation for today's savvy moms

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An advanced formulation for today’s savvy moms See how Nexa® Plus compares to other prenatal vitamins1-6 Prenatal Vitamin

DHA Source

DHA

Vitamin D3

Nexa® Plus

350 mg

800 IU

CitraNatal Harmony®

250 mg

400 IU

PreferaOB® ONE

200 mg

400 IU

Prenate Essential®

300 mg

220 IU

Vitafol® Plus

200 mg

1000 IU

vitaMedMDTM One Rx

200 mg

400 IU

Docusate Stool Softener

All products and trademarks are owned by their respective companies

All-in-one capsule taken once daily with 350 mg DHA Nexa® Plus

• Biotin—  an essential component of enzymes that metabolize carbohydrates and fats1,7

USL NDC#

30-count 0245-0374-30 bottle

•D  ocusate calcium— a gentle stool softener—for added comfort1

WARNING: Accidental overdose of iron-containing products is a leading cause of fatal poisoning in children under 6. KEEP THIS PRODUCT OUT OF THE REACH OF CHILDREN. In case of accidental overdose, call a doctor or poison control center immediately. Please see accompanying Full Prescribing Information for a complete list of warnings and precautions.

Essential nutrition for the next generation www.nexaprenatal.com

• Vitamin  D3— 800 IU to support the skeletal health of mom and her developing baby1,8 • Iron— to support the formation of healthy red blood cells1,9 • F olic acid— in addition to a healthy diet—helps reduce the risk of neural tube defects1,10 •D  HA— a key omega-3 fatty acid—for baby’s prenatal and postnatal brain and eye development1,11-13

References: 1. Nexa Plus [package insert]. Minneapolis, MN: Upsher-Smith Laboratories, Inc; 2012. 2. CitraNatal Harmony [package insert]. San Antonio, TX: Mission Pharmacal Company; 2010. 3. PreferaOB ONE [package insert]. Marietta, GA: Meda Pharmaceuticals, Inc.; 2011. 4. Prenate Essential [package insert]. Atlanta, GA: Avion Pharmaceuticals, LLC; 2012. 5. Vitafol Plus [package insert]. West Orange, NJ: Everett Laboratories, Inc; 2012. 6. vitaMedMD One Rx product information Web site. http://www.vitamedmdrx.com/ SupplementalFactsOneRx.aspx. Accessed July 5, 2012. 7. Biotin. Medline Plus Web site. http://www.nlm.nih.gov/medlineplus/druginfo/ natural/313.html. Accessed May 1, 2012. 8. Mulligan ML, Felton SK, Riek AE, Bernal-Mizrachi C. Implications of vitamin D deficiency in pregnancy and lactation. Am J Obstet Gynecol. 2010;202(5):429.e1-429.e9. 9. Anemia during pregnancy. March of Dimes Web site. http:// www.marchofdimes.com/pnhec/188_1049.asp. Accessed September 28, 2010. 10. Folic acid for a healthy pregnancy and baby. March of Dimes Web site. http://www.marchofdimes.com/pregnancy/folicacid.html. Accessed April 25, 2012. 11. Omega-3 fatty acids, fish oil, alphalinolenic acid. Medline Plus Web site. http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-fishoil.html. Accessed April 25, 2012. 12. Koletzko B, Larque E, Demmelmair H. Placental transfer of long-chain polyunsaturated fatty acids (LC-PUFA). J Perinat Med. 2007;35 (suppl 1):S5-S11. 13. life’sDHA Web site. http://www.lifesdha.com. Accessed May 17, 2012. life’sDHA is a trademark of DSM

© 2012 Upsher-Smith Laboratories, Inc., Maple Grove, MN 55369  106762.01  1-800-654-2299

TM

www.upsher-smith.com

Nexa® Plus Capsules



Rx only

Rx Prenatal Vitamin with Plant-Based DHA from Algal Oil • 1.25 mg Folic Acid and 350 mg DHA (key omega-3 fatty acid) • Essential vitamins and minerals • Gentle stool softener DESCRIPTION: Nexa® Plus Capsules are a prescription prenatal/postnatal multivitamin/ mineral softgel capsule with plant-based DHA. Nexa® Plus Capsules are available as opaque brown, oblong capsules imprinted “0374” and are available in 30-count bottles (NDC 0245-0374-30). Each softgel capsule contains: Vitamin C (ascorbic acid, USP)............................................................................................28 mg Vitamin D3 (cholecalciferol, USP)........................................................................................ 800 IU Vitamin E (d-alpha tocopherol, USP).................................................................................... 30 IU Vitamin B6 (pyridoxine hydrochloride, USP).................................................................................25 mg Folic Acid, USP..................................................................................................................1.25 mg Biotin................................................................................................................................250 mcg Calcium.............................................................................................................................160 mg* Iron (ferrous fumarate, USP)...............................................................................................29 mg Algal oil blend (derived from Crypthecodinium cohnii)..................................................660 mg** Docusate Calcium, USP........................................................................................................55 mg *158 mg calcium from calcium carbonate, USP and 2 mg calcium from docusate calcium, USP **Providing 350 mg DHA (docosahexaenoic acid) Other Ingredients: Ascorbyl palmitate, corn oil, ethyl vanillin, FD&C Yellow #6, FD&C Red #40, FD&C Blue #1, gelatin, glycerin, lecithin, soybean oil, sunflower oil, titanium dioxide, water, yellow beeswax, white ink (ammonium hydroxide, isopropyl alcohol, n-butyl alcohol, propylene glycol, shellac glaze in SD-45 alcohol, simethicone, titanium dioxide). Contains: Soy INDICATIONS: Nexa® Plus Capsules are indicated to provide vitamin/mineral and plant-based DHA supplementation throughout pregnancy, during the postnatal period for both lactating and non-lactating mothers, and throughout the childbearing years. Nexa® Plus may be useful in improving the nutritional status of women prior to conception. CONTRAINDICATIONS: Nexa® Plus Capsules are contraindicated in patients with a known hypersensitivity to any of the ingredients. Do not take this product if you are presently taking mineral oil, unless directed by a doctor.

WARNING: Accidental overdose of iron-containing products is a leading cause of fatal poisoning in children under 6. Keep this product out of reach of children. In case of accidental overdose, call a doctor or poison control center immediately. WARNING: Ingestion of more than 3 grams of omega-3 fatty acids (such as DHA) per day has been shown to have potential antithrombotic effects, including an increased bleeding time and International Normalized Ratio (INR). Administration of omega-3 fatty acids should be avoided in patients taking anticoagulants and in those known to have an inherited or acquired predisposition to bleeding. PRECAUTION: Folic acid alone is improper therapy in the treatment of pernicious anemia and other megaloblastic anemias where vitamin B12 is deficient. Folic acid in doses above 1 mg daily may obscure pernicious anemia in that hematologic remission can occur while neurological manifestations progress. ADVERSE REACTIONS: Allergic sensitization has been reported following both oral and parenteral administration of folic acid. CAUTION: Exercise caution to ensure that the prescribed dosage of DHA does not exceed 1 gram (1000 mg) per day. DOSAGE AND ADMINISTRATION: Before, during and/or after pregnancy, one softgel capsule daily or as directed by a physician. HOW SUPPLIED: Nexa® Plus Capsules are available as opaque brown, oblong capsules imprinted “0374” and are available in 30-count bottles (NDC 0245-0374-30). KEEP THIS AND ALL DRUGS OUT OF THE REACH OF CHILDREN. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects to Upsher-Smith Laboratories, Inc. at 1-888-650-3789. Store at 20° – 25°C (68° – 77°F). [See USP Controlled Room Temperature.] Distributed by: UPSHER-SMITH LABORATORIES, INC. Minneapolis, MN 55447 106431-01





1-800-654-2299 www.upsher-smith.com © 2012 Upsher-Smith Laboratories, Inc. All rights reserved. US Patents 5,407,957; 5,492,938

Revised 0312

107035.01