Books: All about electrospray. - Analytical Chemistry (ACS Publications)

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Analytical methods versus product quality ness testing for product quality and analytical methods, respectively. Each of these chapters presents a good description of factorial analysis for experimental design, describing various approaches to factorial analysis with the advantages and limitations of each approach. However, these chapters also highlight the major difficulty of this book—they are essentially redundant except for the examples used. Chapter 2 describes the methods with respect to Robustness of Analytical tablet crushing strength; Chapter 3 uses an Chemical Methods and HPLC method as the example. Much of the Pharmaceutical discussion and several of the tables are Technological Products repeated in both chapters and often again Margriet M.W.B. Hendriks, Jan H. de Boer, in later chapters. For example tables illusand Age K. Smilde, Eds. tra.ti.nsf a Plackett-Burman design Elsevier Science found in Chapters 2 3 and 5 P.O. Box 945 This alternation between product quality New York, NY 10159-0945 and analytical methodology continues 1996, 345pp,, $243.75 throughout the book. Chapters 2,4, and 8 deal explicitly with product quality or use This is the 19th volume in the serres Data Handling iincience and Technology. The tablet crushing as the only example. Chapeditors' purported aim "is to help those who ters 3,5,6, and 7 deal with the robustness of are working in the area of analytical chemis- analytical methods. In all of these chapters the editors have done a poor job of eliminattry and pharmaceutical technology to deing redundant material. There are even velop robust analysis methods and pharmaceutical technological products." The editors cases of apparently conflicting material. For include discussions of the robustness of both example, in Chapter 3 the author states that analytical methods and pharmaceutical prod- the use of "the type of acid to control the pH of the mobile phase... does not make ucts in the same volume, arguing that "the sense" as an experimental factor. Then in methodology to serve these purposes is essentially the same". Although this statement Chapter 5 the identity of the buffer compO" factor in Table 5.2. may be true, this volume unfortunately does nents is included This inconsistency is of course 3. danger not make the connection clear. The same with an edited volume in which each chapter methodology may apply; however, the people doing the two types of studies are not the is written by different authors; however the same. This dichotomy is evident even in this editors have not done a sufficiently careful job of ensuring that the individual chapters volume as each chapter specifically deals are consistent in style level and focus and with either analytical methods or product that the amount of redundant and conflicting quality This book would have been more material is kept to a minimum useful if the editors had chosen only one of these areas to address and described the The level of the individual chapters is methods and applications in a coherent also very uneven. Although the editors manner state in the introduction the intended audiAt the heart of this book are Chapters 2 ence is those working in the areas of analytical method development and product and 3, which present overviews of robust406 A

Analytical Chemistry News & Features, June 1, 1998

quality, some of the chapters require a significant background in chemometrics. Chapters 2 and 4 are particularly theoretical and require a rather sophisticated background in experimental design. These chapters are likely to be too dense (i.e., the discussion is theoretical rather than example driven) for someone wanting to learn the basics of experimental design and how to apply it. The last three chapters provide a nice conclusion by showing the direct application of the statistical methods described in the previous chapters to TLC, solvent-solvent extraction and tabletcrushing strength. More "real" examples in the earlier chapters would have significantly improved the readability and understandability of this book Reviewed by Craig E. Lunte, University of Kansas

All about electrospray

Electrospray Ionization Mass Spectrometry: Fundamentals, Instrumentation, and Applications Richard B. Cole, Ed. John Wiley & Sons 605 Third Ave. New York, NY 10158 1997, 577 pp., $89.95

This book comprises review articles of studies published up to 1995, wrrtten by experts

in their respective areas of electrospray MS. It has an extensive subject index but no author index. The articles are organized into four parts: fundamentals, coupling to different mass analyzers, interfacing to LC and CE, and applications. In comparison with earlier compilations, this book spans the widest spectrum of topics and is the only one made up entirely of reviews. Overall the book is comprehensive, informative, and very readable. Chapters are well-balanced. There are very few areas of substantial overlap a difficult feat to achieve in view of the large number of authors involved. Exceptions are dynamic range eappearing in several earlier chapters) and source design (both Chapters 3 and 5) Because LC and CE were associated with electrospray MS since the infancy of this technique it is Tint

too surprising to see them appearing in sections of chanters deallng with electrosorav coupled to various mass analvzers (Chanters 5-8) and as the subiects of individual chanters (9 and 10) This reviewer did not tfnd these few repetitive examples bothersome because of the large pool of examples from which to choose The book opens with a preface by John Fenn, the father of biological electrospray, who gives an interesting, anecdotal account of how it all began. There are four chapters in Part I. Chapter 1 is a review of mechanistic studies, which is a detailed, comprehensive account of accepted theory. However, the authors make no mention of potential alternative mechanisms, which gives the reader the impression that most aspects of the electrospray mechanism are understood. Chapter 2 describes the electrolytic nature of electrospray and highlights applications that exploit the electrolytic process. Chapter 3 covers source design and dynamic range in electrospray MS the former of which tends to be neglected in journal I enjoyed reading this chapter but would have preferred a more in-depth treatment particularly in

sections dealing with the comparison of BOOKS RECEIVED various instrumental designs. Chapter 4 summarizes the contributions of solution, Solid-Phase Extraction: gas-phase, and instrumental parameters to Principles and Practice charge-state distribution in electrospray E. M. Thurman and M. S. Mills MS. The review is lucid and succinct. John Wiley & Sons Four chapters discuss performing 605 Third Ave. electrospray on various types of mass analyz- New York, NY 10158 ers: quadrupoles and sector instruments, 1998, 344 pp., $49.95 time-of-flight (TOF) analyzers, ion traps, and ion-cyclotron-resonance (ICR) spectromeDivided into three main sections, the book ters. All the chapters are well-wriiten and opens with the basic concepts underlying informative. I particularly enjoyed reading solid-phase extraction (SPE), including the sections on noncovalent associations of theory, chemistry, mechanisms of interacbiomolecules using TOF MS and on compar- tion, method development, troubleshooting various designs to accommodate electro- ing, and optimization. The second part of spray in ICR spectrometers. the book focuses on applications, with sepPart III is dedicated to interfacing electro- arate chapters on clinical, environmental, spray to LC and CE. Key aspects in develop- and natural product chemistry. The final section describes the latest SPE technoling successful analyses with LC are described. The art of interfacing CE to electro- ogy, including automation and microextractions. Suggested reading, ,nternet respray is also reviewed, and a number of sources and product guides are included interesting and exemplary applications are throughout the book. highlighted. The remaining five chapters deal with various types of appllcattons. The account of applications in the peptide and Mass Spectrometry of protein area is particularly readable and inBiological Materials, 2nd ed. formative. This section also reviews the nuBarbara S. Larsen and Charles N. McEwen, cleic acid area, carbohydrates and lipids, Eds. drug metabolism and pharmacokinetics, and Marcel Dekker inorganic and organometallic complexes. 270 Madison Ave. These chapters are all comprehensive and New York, NY 10016 will well as a source of reference in 1998, 469 pp.. $195 thf^Qf a r p f l s for" t n i i f w vf*jit*Q I n c C\TY\(* T T I I Q

reviewer especially enjoyed reading the last chapter which stands out in the thoroughness of its review and scope of its coverage It was with some reluctance that I agreed to review a book of this length. Having read and learned much from it, I am glad that I did. I would recommend this book to any mass spectrometrist who is interested in electrospray, from the neophyte to the seasoned practitioner. We can all benefit from it. Reviewed by K. W. Michael Siu, York University (Cananad

This revised and expanded edition reviews new ionization methods and advances in mass spectrometers used in biological analyses. The book describes how databases are used in the identification of proteins from mass spectral data. In addition, essential parameters for the analysis of low levels of complex biological materials are included. Noncovalent interactions, tertiary structure determination, and the characterization of oligonucleotides and DNA are also explained. An index is included.

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