Fact Sheet

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4Q17 Global & International Equity

Global Technology Fund D: JNGTX

as of 12/31/17

Fund Description

INVESTMENT STYLE

This global growth fund invests in companies that create and benefit from advances in technology. We invest in companies we believe to be resilient and also take smaller positions in companies that have optionality – meaning large potential upside under a specific scenario. The Fund seeks to provide strong long-term returns with volatility characteristics on par with its peers.

SMALL

MID

LARGE

X

VALUE

BLEND GROWTH

MARKET CAPITALIZATION

Morningstar Style Box™ Category Technology

4Q17

1 yr

3 yr

5 yr

10 yr

Since Inception (12/31/98)

Class D Shares

7.78

44.73

19.85

20.55

11.96

8.79

S&P 500® Index

6.64

21.83

11.41

15.79

8.50

6.17

MSCI All Country World Information Technology IndexSM

8.10

41.77

17.96

19.06

9.90

5.41

Portfolio Management

Performance (%)

Brad Slingerlend, CFA Denny Fish

Fund Characteristics Inception Date

12/31/98

Assets

$2.38B

Returns quoted are past performance and do not guarantee future results; current performance may be lower or higher. Investment returns and principal value will vary; there may be a gain or loss when shares are sold. For the most recent month-end performance call 800.525.3713 or visit janushenderson.com/allfunds.

76

High absolute short-term performance is not typical and may not be achieved in the future. Such results should not be the sole basis for evaluating material facts in making an investment decision.

Number of Holdings Equity Issues Turnover (1 year trailing)

23.91%

Weighted Average Market Cap

$220.59B

Distribution Frequency

Annually

Expense Ratios (%) Class D

Calendar Year Returns (%)

Class D Shares

Gross

Net

0.88

0.88

Net expense ratios reflect the expense waiver, if any, contractually agreed to through 2/1/19.

2008 2009 2010

2011

2012 2013 2014 2015 2016 2017

-43.27 57.29 24.64 -8.41 19.31 35.24

MSCI All Country World Information -44.63 58.13 Technology IndexSM

9.35

4.55 13.76 44.73

11.35 -4.43 15.32 26.51 15.20

3.20 12.20 41.77

Hypothetical Growth of $10,000 Since Benchmark Inception Class D Shares

MSCI All Country World Information Technology IndexSM

$30,000

$23,977 $23,358

$20,000 $10,000 $0 12/30/00 Source: Morningstar, Inc.

2004

2006

2008

2010

2012

2014

12/31/17

Performance for Class D Shares that includes periods prior to 2/16/10 reflects the performance of one or more share classes of the Fund or a predecessor fund, adjusted, where applicable and permitted, for differing fees and expenses. See the Fund's prospectus for further details. Returns include reinvestment of dividends and capital gains. Returns greater than one year are annualized. Continued on back page.

Global Technology Fund (as of 12/31/17) Risk Statistics (3 Year)

Fund

Index

Top Countries (%)

Fund

Index

74.76

69.47

Alpha

1.53

—

United States

Beta

1.02

1.00

China

9.24

7.99

R-squared (%)

94.60

100.00

Korea, Republic Of

2.62

4.57

Standard Deviation

14.49

13.87

Taiwan, Province Of China

2.57

4.58

1.35

1.27

Netherlands

2.19

1.30

Japan

1.26

5.56

Brazil

1.22

0.26

Canada

0.90

0.57

Australia

0.57

0.11

Israel

0.45

0.23

Sharpe Ratio Statistics are for Class I Shares.

Developed vs. Emerging Market Exposure (%)

Fund

Index

U.S.

74.74

69.46

Non-U.S. Emerging

16.04

18.28

Non-U.S. Developed

5.77

12.26

Cash & Equivalents

3.45

—

Regions (%)

Fund

Index

North America

75.66

70.04

Asia/Pacific Ex Japan

15.38

18.14

Europe

2.58

5.78

Japan

1.26

5.55

Latin America

1.22

0.26

Africa/Mideast

0.45

0.23

Top Holdings (%)

Fund

Microsoft Corp

6.24

Alphabet Inc

5.75

Tencent Holdings Ltd

4.14

salesforce.com Inc

3.85

Alibaba Group Holding Ltd (ADR)

3.29

Amphenol Corp

3.13

Adobe Systems Inc

Market Capitalization Range of Equity Holdings (%)

Fund

Index

Over $100B

39.71

59.65

$50B to $100B

13.54

10.85

$10B to $50B

23.52

23.58

$5B to $10B

9.65

4.29

$1B to $5B

8.46

1.14

$500M to $1B

0.57

—

$100M to $250M

0.25

—

N/A

0.85

0.49

Top Industries (%)

Fund

Index

Internet Software & Services

22.73

22.29

Application Software

17.40

5.90

Semiconductors

13.31

14.46

Systems Software

7.00

10.83

Internet & Direct Marketing Retail

5.95

—

2.71

Technology Hardware, Storage & Peripherals

4.95

16.87

Facebook Inc

2.63

Electronic Components

3.13

2.74

Samsung Electronics Co Ltd

2.62

IT Consulting & Other Services

3.02

5.71

Taiwan Semiconductor Manufacturing Co Ltd

2.57

Home Entertainment Software

2.96

1.91

Electronic Manufacturing Services

2.84

1.38

Total

36.93

For more information, please visit janushenderson.com. Index represents the MSCI All Country World Information Technology IndexSM. Holdings are subject to change without notice. For a complete list of holdings as of the most recent publicly available disclosure period, visit janushenderson.com/reports. Equity country, regional, sector and industry weights based on MSCI and GICS classifications. Fixed income country, regional, sector and industry weights based on Barclays classifications. Performance may be affected by risks that include those associated with nondiversification, portfolio turnover, short sales, potential conflicts of interest, foreign and emerging markets, initial public offerings (IPOs), high-yield and high-risk securities, undervalued, overlooked and smaller capitalization companies, real estate related securities including Real Estate Investment Trusts (REITs), derivatives, and commoditylinked investments. Each product has different risks. Please see the prospectus for more information about risks, holdings and other details. Foreign securities are subject to additional risks including currency fluctuations, political and economic uncertainty, increased volatility, lower liquidity and differing financial and information reporting standards, all of which are magnified in emerging markets. Index performance does not reflect the expenses of managing a portfolio as an index is unmanaged and not available for direct investment. S&P 500® Index reflects U.S. large-cap equity performance and represents broad U.S. equity market performance. MSCI All Country World Information Technology IndexSM reflects the performance of information technology stocks from developed and

emerging markets. Alpha compares risk-adjusted performance relative to an index. Positive alpha means outperformance on a risk-adjusted basis. Beta measures the volatility of a security or portfolio relative to an index. Less than one means lower volatility than the index; more than one means greater volatility. R-squared (R2) measures the relationship between portfolio and index performance on a scale of 0.00 (0%) to 1.00 (100%). A higher R2 indicates more of the portfolio's performance is affected by market movements and vice versa. Standard Deviation measures historical volatility. Higher standard deviation implies greater volatility. Sharpe Ratio measures risk-adjusted performance using excess returns versus the "risk-free" rate and the volatility of those returns. A higher ratio means better return per unit of risk.

Please consider the charges, risks, expenses and investment objectives carefully before investing. For a prospectus or, if available, a summary prospectus containing this and other information, please call Janus Henderson at 800.525.3713 or download the file from janushenderson.com/reports. Read it carefully before you invest or send money. Janus Henderson is a trademark of Janus Henderson Investors. © Janus Henderson Investors. The name Janus Henderson Investors includes HGI Group Limited, Henderson Global Investors (Brand Management) Sarl and Janus International Holding LLC. Janus Henderson Distributors C-1217-14327 04-15-18 299-15-27770 01-18