Low Thermal Mass Liquid Chromatography - Analytical Chemistry

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Anal. Chem. 2009, 81, 1488–1495

Low Thermal Mass Liquid Chromatography Binghe Gu,† Hernan Cortes,*,† Jim Luong,‡ Matthias Pursch,§ Patric Eckerle,§ and Robert Mustacich| The Dow Chemical Company, Analytical Sciences, 1897 Building, Midland, Michigan 48667, The Dow Chemical Company, Fort Saskatchewan, Canada, The Dow Chemical Company, Rheinmunster, Germany, and RVM Scientific, Santa Barbara, California A novel technique, low thermal mass liquid chromatography (LTMLC), is introduced in this study. The use of an LTM assembly that utilizes the principle of resistive wire heating and a temperature sensor to accurately deliver unprecedented heating (up to 1800 °C/min) or cooling (100∼200 °C/min) rates is reported. With the use of packed microcolumns (